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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(2): 31-37

Changes of neuromuscular transmission in smooth muscles of rats bladder with experimental diabetes

Vladimirova IA1, Filippov IB1, Paduraru ON2, Shuba ÉIa1, Kuliieva ÉM1, Shuba IaM1,2,3

  1. Bogomoletz Institute of physiology NAS of Ukraine, Kyiv;
  2. International Center for Molecular Physiology, Kyiv, Ukraine
  3. State key Laboratory of Molecular. and cells. physiology, Kyiv


Literary data show that in patients with sugar- nerve regulation of visceral smooth muscle is broken. We investigated the contribution of cholinergic and purinergic components of neuromuscular transmission in the reduction of strips of smooth muscle detrusora (HMD) of control rats and rats with streptozotocininduci- diabetes mellitus in response to electrical stimulation, and the application of exogenous carba- cholesterol (KX, 1 μmol / L) and ATP (1 mmol / L). We managed to two types of contractile reactions of the KMD patients animals. The first type, which occurred in 80% of all studied strips of diabetic rats, characterized by The absence of changes in the amplitude and kinetics synaptic-induced abbreviations and effects on CX application, but the strengthening of the contractile response to application of exogenous ATP in comparison with the control. The second type of reaction, observed in the remaining 20% drugs, was to increase the duration synaptic-induced contractions due to greater contribution to them cholinergic component, statistically significant increase in response to exogenous CX and even greater reductions in the application exogenous ATP in comparison with the control. Our results to some extent explain the differences in literary data on the impact of experimental diabetes on neuromuscular transmission in the KMD. Establishing reasons revealed heterogeneity of synaptic transmission at diabetes require further research.

Keywords: diabetes, bladder, smooth- Muscle, contraction, neuromuscular transmission.


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