Changes of neuromuscular transmission in smooth muscles of rats bladder with experimental diabetes
Vladimirova IA1, Filippov IB1, Paduraru ON2, Shuba ÉIa1, Kuliieva ÉM1, Shuba IaM1,2,3
- Bogomoletz Institute of physiology NAS of Ukraine, Kyiv;
- International Center for Molecular Physiology, Kyiv, Ukraine
- State key Laboratory of Molecular. and cells. physiology, Kyiv
Literary data show that in patients with sugar-
nerve regulation of visceral smooth
muscle is broken. We investigated the contribution of cholinergic
and purinergic components of neuromuscular
transmission in the reduction of strips of smooth muscle detrusora
(HMD) of control rats and rats with streptozotocininduci-
diabetes mellitus in response to electrical
stimulation, and the application of exogenous carba-
cholesterol (KX, 1 μmol / L) and ATP (1 mmol / L). We managed to
two types of contractile reactions of the KMD patients
animals. The first type, which occurred in 80% of all
studied strips of diabetic rats, characterized by
The absence of changes in the amplitude and kinetics
synaptic-induced abbreviations and effects on
CX application, but the strengthening of the contractile response to
application of exogenous ATP in comparison with the control.
The second type of reaction, observed in the remaining 20%
drugs, was to increase the duration
synaptic-induced contractions due to greater
contribution to them cholinergic component, statistically
significant increase in response to exogenous
CX and even greater reductions in the application
exogenous ATP in comparison with the control. Our results
to some extent explain the differences in literary
data on the impact of experimental diabetes on
neuromuscular transmission in the KMD. Establishing reasons
revealed heterogeneity of synaptic transmission at
diabetes require further research.
diabetes, bladder, smooth- Muscle, contraction, neuromuscular transmission.
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