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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(2): 25-30

The activity of interferon-dependent 2',5'-oligoadenylatesynthetase in rat thymus lymphoid cells under the action of ethanol and acetic zinc administration

Kompanets' IV, Stepanets' IO, Voĭtenko VV, Hrebinyk DM, Ostapchenko LI.

    Taras Shevchenko National University, Kyiv, Ukraine


The activity of interferon-induced 2',5'oligoadenylatesynthetase (2ЃЊ,5ЃЊ-OA-synthetase) in thymocytes of rats simultaneously treated with ethanol and acetic zinc preparation was studied. The 2',5'-OA-synthetase activity was decreased by 75% after daily ethanol administration for 14 days. The changes were less pronounced at the late terms of the experiment. In vitro stimulation of enzyme activity by inducer cycloferon was more pronounced at the late terms of ethanol action. Combined administration of ethanol and acetic zinc increased the 2',5'-OA-synthetase activity (by 81% at 21th day and by 30% at 28th day) in comparison to the group of animals that consumed ethanol only. The zinc preparation augmented the stimulation of enzyme activity induced by cycloferon, the effect was most prominent at the late terms of the ethanol action (at 28th day). Probably, ethanol depresses the synthesis of interferon or disturbs the functioning of 2ЃЊ,5ЃЊ-oligoadenylate cascade. The acetic zinc amplifies the interferon synthesis.

Keywords: alcohol intoxication, interferon, 2',5'-oligoadenylatesynthetase,thymocytes. cycloferon


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