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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 91-97

The use of aluminum and its compounds for the biomedical purposes

Bohuts'ka KI, Pryluts'kyĭ IuI, Nozdrenko DM.

    Taras Shevchenko National University, Kyiv, Ukraine


Taking into consideration the nanodimension of functional components of living cells, the application of nanotechnology К.І. Богуцька, Ю.І. Прилуцький, Д.М. Ноздренко 69ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 1 in the biomedical purposes is currently an urgent task. One of these directions is the use of aluminum nanoparticles for molecular diagnostics, targeted delivery of drugs, the development of new pharmaceuticals. The action of aluminum chloride on the regulatory mechanisms of smooth and skeletal muscle contraction and also the effect of aluminum ions on the ATPase activity and superprecipitation of actomyosin of different types of muscles is discussed.

Keywords: aluminum, contraction, muscles.


  1. Andrusishina I.N. Metal nanoparticles: ways of receiving, physical and chemical properties, methods of research and toxicity assessment. Modern Problems Toxicol 2011; 3: 5-14.
  3. Bogutska K. Comparative studies of modulating ion aluminumATP-ase activity of cardiac myosin and smooth muscle. Bulletin of Kiev National Taras Shevchenko University. Biology 2012; 60: 25-7.
  5. Bogutska K.I., Danilova V.M., Minchenko P.G., Sheremet L.P., Miroshnichenko M.S. Influence of aluminium ions on superprecipitation of the cardiac and skeletal muscle actomyosin. Biopolymers and cell 2003; 19(4): 362-6. CrossRef  
  6. Bogutska K.I., Prylutskyy Yu.I., Sklyarov Yu.P. The influence of aluminum ions on actomyosin superprecipitation and myosin ATPase activity in cardiac muscle. UkrainicaBioorganica Acta 2011; 9(2): 41-5.
  8. Buchold D.H., Feldmann C. Nanoscale gamma-AlO(OH) hollow spheres: synthesis and container-type functionality. Nano Lett 2007 Nov; 7(11): 3489-92. CrossRef PubMed
  10. Clapp T., Siebert P., Chen D., Jones Braun L. Vaccines with aluminum-containing adjuvants: optimizing vaccine efficacy and thermal stability. J Pharm Sci 2011 Feb; 100(2): 388-401. CrossRef PubMed PubMedCentral
  12. Dastjerdi R., Montazer M. A review on the application of inorganic nano-structured materials in the modification of textiles: focus on anti-microbial properties. Colloids Surf B Biointerfaces 2010 Aug 1; 79(1): 5-18. CrossRef PubMed
  14. Davidovskaya T.L., Bogutska K.I. Modulatory effect of aluminum ions on smooth muscle contraction. Neurophysiology 2003; 35(3/4): 342. CrossRef  
  15. Davidovskaya T.L., Bogutska K.I., Minchenko P.G., Miroshnichenko N.S. Modulatory effect of aluminium and its complex with quercetin of muscle contractile regulatorty mechanisms. Biopolymers and cell 1998; 14(6): 534-9. CrossRef  
  16. Geho D.H., Lahar N., Ferrari M., Petricoin E.F., Liotta L.A. Opportunities for nanotechnology-based innovation in tissue proteomics. Biomed Microdevices 2004 Sep; 6(3): 231-9. CrossRef PubMed
  18. Gura K.M. Aluminum contamination in products used in parenteral nutrition: has anything changed? Nutrition 2010 Jun; 26(6): 585-94. CrossRef PubMed
  20. Gurjar M., Baronia A.K., Azim A., Sharma K. Managing aluminum phosphide poisonings. J Emerg Trauma Shock 2011 Jul; 4(3): 378-84. CrossRef PubMed PubMedCentral
  22. Hernandez-Sanchez A., Tejada-Gonzalez P., Arteta- Jimenez M. Aluminium in parenteral nutrition: a systematic review. Eur J Clin Nutr 2013 Mar; 67(3): 230-8. CrossRef PubMed
  24. Kim I.S., Baek M., Choi S.J. Comparative cytotoxicity of Al2O3, CeO2, TiO2 and ZnO nanoparticles to human lung cells. J Nanosci Nanotechnol 2010 May; 10(5): 3453-8. CrossRef PubMed
  26. Kotsan I.Ya., Miroshnichenko M.S., Makarchuk M.Yu., Nozdrenko D.M., Melnichuk O.M. Influence of aluminium compounds on the muscle fiber contraction. «Biomineralogy-2008». Sonf materials 2008: 101-106.
  28. Kumar V., Gill K.D. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch Toxicol 2009 Nov; 83(11): 965-78. CrossRef PubMed
  30. Loomba L., Scarabelli T. Metallic nanoparticles and their medicinal potential. Part II: aluminosilicates, nanobiomagnets, quantum dots and cochleates. Ther Deliv 2013 Sep;4(9): 1179-96. CrossRef PubMed
  32. Medina C., Santos-Martinez M.J., Radomski A., Corrigan O.I., Radomski M.W. Nanoparticles: pharmacological and toxicological significance. Br J Pharm 2007 Mar; 150(5):552-8. CrossRef PubMed PubMedCentral
  34. Mehrpour O., Jafarzadeh M., Abdollahi M. A systematic review of aluminium phosphide poisoning. Arh Hig Rada Toksikol 2012 Mar; 63(1): 61-73. CrossRef PubMed
  36. Miroshnichenko M.S., Davidovskaya T.L., Nuryshchenko N.E., Bogutska K.I. Influence of aluminium compounds on the smooth muscles functioning and skeletal muscle contractile proteins. «Biomineralogy-2008». Sonf materials2008: 97-101.
  38. Miroshnichenko M.S., Minchenko P.G., Shuba M.F. Aluminium impact on actomyosin precipitation. DAN of Ukr 1993; 6: 78-81.
  40. Nayak P. Aluminium: impacts and disease. Environ Res 2002 Jun; 89(2): 101-15. CrossRef PubMed
  42. Peto M.V. Aluminium and iron in humans: bioaccumulation, pathology and removal. Rejuvenation Res 2010 Oct; 13(5): 589-98. CrossRef PubMed
  44. Poinern G.E.J., Ali N., Fawcett D. Progress in nano-engineered anodic aluminum oxide membrane development. Materials 2011; 4(3): 487-526. CrossRef PubMed PubMedCentral
  46. Prabhakar P.V., Reddy U.A., Singh S.P., Balasubramanyam A., Rahman M.F., Indu Kumari S. et al. Oxidative stress induced by aluminum oxide nanomaterials after acute oral treatment in Wistar rats. J Appl Toxicol 2012 Jun; 32(6): 436-45. CrossRef PubMed
  48. Proudfoot A. Aluminium and zinc phosphide poisoning. Clin Toxicol (Phila) 2009 Feb; 47(2): 89-100. CrossRef PubMed
  50. Radziun E., Dudkiewicz Wilczynska J., Ksiazek I., Nowak K., Anuszewska E.L., Kunicki A. et al. Assessment of the cytotoxicity of aluminium oxide nanoparticles on selected mammalian cells. Toxicol In Vitro 2011 Dec; 25(8): 1694-700. CrossRef PubMed
  52. Rudenko S.S., Ozerova I.O., Ribitzka M.M., Voloshchuk K.O. The influence of aluminum intoxication and g-irradiation on the state of body's antioxidant system and the possibility of its managing. Ukr Biokhim Zh 1998; 70(2):84-8.
  54. Ruhland T., Nielsen S.D., Holm P., Christensen C.H. Nanoporous magnesium aluminometasilicate tablets for precise, controlled, and continuous dosing of chemical reagents and catalysts: applications in parallel solutionphase synthesis. J Comb Chem 2007 Mar-Apr; 9(2): 301-5. CrossRef PubMed
  56. Shalunov E.P., Matrosov A.L., Shvedov M.A. Granulated aluminum nanocomposition materials in extreme conditions of operation. II Russ Conf Nanomatter «NANO 2007»; 2007: 406-7.
  58. Skalniy A.V., Rudakov I.A. Bioelements in medicine. Moscow: «Onix 21 Century», 2004: 272 p.
  60. Stanley J.K., Coleman J.G., Weiss C.A., Steevens J.A. Sediment toxicity and bioaccumulation of nano and micron-sized aluminum oxide. Environ Toxicol Chem 2010 Feb; 29(2): 422-9. CrossRef PubMed
  62. Sun J., Wang S., Zhao D., Hun F.H., Weng L., Liu H. Cytotoxicity, permeability, and inflammation of metal oxide nanoparticles in human cardiac microvascular endothelial cells: cytotoxicity, permeability, and inflammation of metal oxide nanoparticles. Cell Biol Toxicol 2011 Oct; 27(5):333-42. CrossRef PubMed
  64. Tomljenovic L., Shaw C.A. Aluminum vaccine adjuvants: are they safe? Curr Med Chem 2011; 18(17): 2630-7. CrossRef PubMed
  66. Wickline S.A., Lanza G.M. Nanotechnology for molecular imaging and targeted therapy. Circulation 2003 Mar 4;107(8): 1092-5. CrossRef PubMed
  68. Willhite C.C., Ball G.L., McLellan C.J. Total allowable concentrations of monomeric inorganic aluminum and hydrated aluminum silicates in drinking water. Crit Rev Toxicol 2012 May; 42(5): 358-442. CrossRef PubMed
  70. Yamamoto Y., Katoh Y., Sato T. Determination of aluminum in various biological materials using instrumental neutron activation analysis. Leg Med (Tokyo) 2009 Apr; 11 Suppl 1: S440-2. CrossRef PubMed
  72. Zhang X.Q., Yin L.H., Tang M., Pu Y.P. ZnO, TiO2, SiO2 nd Al2O3 nanoparticles-induced toxic effects on human fetal lung fibroblasts. Biomed Environ Sci 2011 Dec;24(6): 661-9. PubMed

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