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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 64-69

Study of calcium channels in the mitochondrial membrane of endothelial cells

Bondarenko OI.

  1. Bogomoletz Institute of Physiology, Kyiv, Ukraine;
  2. Institute of Molecular Biology and Biochemistry, Medical University of Graz, Austria


Mitochondria play a central role in the regulation of cell function. Ca2+ entry into mitochondria represents a central event in the regulation of ATP production, intracellular Ca2+ homesotasis and mitochondrial permeability transition pore opening. Until recently, our understanding of the mechanisms of mitochondria Ca2+ uptake was largely limited by the use of indirect optical methods. Utilization of patch-clamp method to isolated mitoplasts allowed characterizing single channel properties of Ca2+ permeable channels in the inner mitochon- Дослідження кальцієвих каналів мітохондріальної мембрани ендотеліальних клітин ISSN 0201-8489 Фізіол. журн., 2014, Т. 60, № 1 69 drial membrane. Here we show the presence of three types of single channel activities of Ca2+ permeable channels in mitoplasts isolated from endothelial cells. While the identity and molecular structure of these channels still remain to be identified, these findings point for complex mechanisms of Ca2+ entry in mitochondria.

Keywords: mitochondria, calcium channels, patch-clamp.


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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.