Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke
Savchuk OI1, Mel'nyk VS1, Goncharov SV1, Shandiuk VIu1, Stroĭ DO1, Dosenko VIe1, Sokolova LI1, Skybo HH1,2
- O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
- State Key Laboratory of Molecular and Cellular Biology, Ukraine
DOI: https://doi.org/10.15407/fz60.01.049

Abstract
Frequency of allelic variants of proteasome subunits genes LMP2
(Arg60>His) and PSMA6 were determined in patients with
ischemic stroke using real-time PCR. Allelic variants of PSMA6
were disposed in the next manner: C/С – 80,2%, С/G – 19,8%,
G/G – were not (in control) and C/С – 75,5%, С/G – 21,4%, G/G
– 3,1% (Р=0,22) in patients with IS. It was shown that distribution
of LMP2 allelic variants was the following: Arg/Arg – 53,3%,
Arg/His – 43,5%, His/His – 6,7% in control and Arg/Arg – 55,9%,
Arg/His – 34,3%, His/His – 9,8% in IS group (P>0,05). The data
show that LMP2 and PSMA6 gene polymorphism is not a risk
factor of ischemic stroke in Ukrainian population.
Keywords:
proteasome, single nucleotide polymorphism, ischemic stroke.
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