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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 49-55


Frequency of allele polymorphism of immune proteasome catalytic subunits in patients with ischemic stroke

Savchuk OI1, Mel'nyk VS1, Goncharov SV1, Shandiuk VIu1, Stroĭ DO1, Dosenko VIe1, Sokolova LI1, Skybo HH1,2

  1. O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
  2. State Key Laboratory of Molecular and Cellular Biology, Ukraine
DOI: https://doi.org/10.15407/fz60.01.049

Abstract

Frequency of allelic variants of proteasome subunits genes LMP2 (Arg60>His) and PSMA6 were determined in patients with ischemic stroke using real-time PCR. Allelic variants of PSMA6 were disposed in the next manner: C/С – 80,2%, С/G – 19,8%, G/G – were not (in control) and C/С – 75,5%, С/G – 21,4%, G/G – 3,1% (Р=0,22) in patients with IS. It was shown that distribution of LMP2 allelic variants was the following: Arg/Arg – 53,3%, Arg/His – 43,5%, His/His – 6,7% in control and Arg/Arg – 55,9%, Arg/His – 34,3%, His/His – 9,8% in IS group (P>0,05). The data show that LMP2 and PSMA6 gene polymorphism is not a risk factor of ischemic stroke in Ukrainian population.

Keywords: proteasome, single nucleotide polymorphism, ischemic stroke.

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