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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 41-48

Exocrine function of the pancreas in rats with experimental obesity

Leshchenko IV1, Shevchuk VH1, Savcheniuk OA2, Falalieieva TM2, Sukhodolia SA3, Berehova TV2.

  1. O.O. Bogomoletz National Medical University, Kyiv, Ukraine
  2. Taras Shevchenko National University, Kyiv, Ukraine
  3. M.I. Pirogov National Medical University, Vinnitsa, Ukraine


The inIuence of neonatal administration of hyperosmolar sodium chloride and sodium glutamate on the exocrine function of the pancreas in rats has been investigated. It was observed the development of acute pancreatitis under experimental obesity. The cross-section area of acini reduced by 12 %, the cross-section area of acinocytes nuclei increased by 10 %, the length between the lobes of the gland has grown by 48 %. The level of amylase was increased by 43 %, the levels of pancreatic amylase and lipase were increased by 68 % and 24 %, respectively

Keywords: obesity, hyperosmolar sodium chloride, monosodium glutamate, pancreas, acute pancreatitis.


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