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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 18-24

The influence of dietary omega-3 polyunsaturated fatty acids on functional parameters of myocardial mitochondria during isoproterenol-induced heart injury

Panasiuk OS, Shysh AM, Moĭbenko OO.

    O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine


We have studied the functional parameters of mitochondria from hearts after isopreterenol-induced injury (two subcutane- ous injections of isopreterenol at the dose 60 mg/kg/day). We investigated the inruence of dietary ?-3 polyunsaturated fatty acids (?-3 PUFAs) administered to rats (Epadol, 0.1mg/100 gr of weight for 4 weeks) on these parameters. Isoproterenol- induced heart injury leads to a decreased parameters of respi- ration of isolated mitochondria in the presence of succinate. Administration of ?-3 PUFAs significantly restored the respiration rate of mitochondria: the state 3 respiration was increased by 70,12 %, the state 4 by 39,87 % and the respira- tory control ratio by 45,19 % compared to the corresponding parameters of experimental group. Also, it was shown the ability of ?-3 PUFAs to decrease mitochondria swelling (by 60%) in nominally free calcium solution. The results of the study indicate that ?-3 PUFAs improve the altered functions of the heart mitochondria evoked by isoproterenol-induced injury. Key words: mitochondria, ?-3 polyunsaturated fatty acids, isopreterenol.

Keywords: mitochondria, ω-3 polyunsaturated fatty acids, isopreterenol


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