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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 18-24


The influence of dietary omega-3 polyunsaturated fatty acids on functional parameters of myocardial mitochondria during isoproterenol-induced heart injury

Panasiuk OS, Shysh AM, Moĭbenko OO.

    O.O. Bogomoletz Institute of Physiology National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz60.01.018

Abstract

We have studied the functional parameters of mitochondria from hearts after isopreterenol-induced injury (two subcutane- ous injections of isopreterenol at the dose 60 mg/kg/day). We investigated the inruence of dietary ?-3 polyunsaturated fatty acids (?-3 PUFAs) administered to rats (Epadol, 0.1mg/100 gr of weight for 4 weeks) on these parameters. Isoproterenol- induced heart injury leads to a decreased parameters of respi- ration of isolated mitochondria in the presence of succinate. Administration of ?-3 PUFAs significantly restored the respiration rate of mitochondria: the state 3 respiration was increased by 70,12 %, the state 4 by 39,87 % and the respira- tory control ratio by 45,19 % compared to the corresponding parameters of experimental group. Also, it was shown the ability of ?-3 PUFAs to decrease mitochondria swelling (by 60%) in nominally free calcium solution. The results of the study indicate that ?-3 PUFAs improve the altered functions of the heart mitochondria evoked by isoproterenol-induced injury. Key words: mitochondria, ?-3 polyunsaturated fatty acids, isopreterenol.

Keywords: mitochondria, ω-3 polyunsaturated fatty acids, isopreterenol

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