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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2014; 60(1): 11-17

Morphofunctional state of reproductive system of ageing male rats in case of using nanocerium

Nosenko ND, Zholobak NM, Poliakova LI, Sinitsyn PV, Lymarieva AA, Shcherbakov OV, Spivak MIa2, Reznikov OH.1

  1. State Institution “V.P. Komissarenko institute of endocrinology and metabolism of National Academy of medical Sciences of Ukraine”, Kyiv, Ukraine;
  2. D.K. Zabolotny Institute of microbiology and Virology of National Academy of Sciences of Ukraine, Kyiv, Ukraine


The inruence of nanocrystalline cerium dioxide (NCD, 1 and 100 mg/kg per os daily for 10 days) on morphofuctional state of reproductive system was investigated in ageing male rats. It has been established that activation of hormone-producing testicular leydig’s cells, as well as of secretory and prolifera- tive processes in prostate, underlies the stimulating effect of NCD at a dose 1 mg/kg on hormonal function of testis and spermatogenesis of ageing male rats. NCD used at a dose 100 mg/kg had no signi%cant effect on the assessed indices of morphofuctional state of reproductive system. Key words: nanocrystalline cerium dioxide, testes, prostate, male rats, ageing.


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© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.