Effects of the prenatal hypoxia on the hypothalamic-pituitary-adrenal axis function and working memory in rats
Tiul'kova EI, Vataeva LA, Glushchenko TS, Pivina SG
Pavlov Institute of Physiology RAS, St.Petersburg, Russia
Abstract
A comparative analysis of the effects of severe hypobaric hypoxia in different prenatal periods on expression profiles of glucocorticoid receptors (GR) in dorsal (CA1) and ventral (dental gyrus) hippocampus and neocortex of rats, their stress reactivity and working memory has been performed in the present study for the first time. According to the data obtained, severe hypoxia in the prenatal period induces remarkable disturbances of GR expression in the neurons of neocortex of adult males but not females, that correlates to the disruption of working memory in adult males exposed to hypoxia on the prenatal 14-16th days. Elevation of stress plasma corticosterone levels have been observed only in the females subjected to hypoxia on the prenatal 17-19th days. Hypoxia in the females and males results in the differential changes in functions of hippocampus, as well as of other brain areas involved in learning.
Keywords:
prenatal hypoxia, hippocampus, neocortex, glucocorticoidreceptors, hypothalamіс pituitary adrenal axis, working memory
References
Arshavskii I.A. Fiziologicheskie mehanizmi i zakonomernosti individual'nogo razvitiya. M.: Nauka, 1982. 270 p.
Vataeva L. A., Kostkin V. B., Makuhina G. V., Hozhai L. I., Otellin V. A. Povedenie v «otkritom pole» u samok i samtsov kris, podvergavshihsya deistviyu gipoksii v razlichnie sroki prenatal'nogo perioda razvitiya . DAN. 2001. 380, N 1. P. 1-3.
Vataeva L.A. Kostkin V.B., Makuhina G.V., Hozhai L.I., Otellin V.A. Uslovnoreflektornaya reaktsiya passiv- nogo izbeganiya u samok i samtsov kris, podvergshihsya vozdeistviyu gipoksii v razlichnie sroki prenatal'- nogo perioda razvitiya. Zhurn. evolyuts. biohimii i fiziologii. 2004. 40, N 3. P. 250-253.
Vataeva E.I., Tyul'kova E.I. Hozhai L.I., Otellin V.A., Samoilov M.O. Obuchenie v vodnom labirinte Morrisa samok i samtsov kris, podvergavshihsya dei- stviyu gipoksii v razlichnie sroki prenatal'nogo perioda razvitiya . Tam zhe. 2005. 41. P. 532-535.
Dmitriev Yu. S., Bachmanov A. A., Dmitrieva N. I., Gots- tso S, Yakobino K., D’Udins B. Nekotorie osobennosti v strukture gippokampa kak neiroanatomicheskaya osnova razlichii v povedenii . Tam zhe. 1987. 23, N 5. P.663-667.
Dubrovskaya N.M., Zhuravin I.A. Ontogeneticheskie osobennosti povedeniya kris, perenesshih gipoksiyu na 14-e ili 18-e sutki embriogeneza . Zhurn. vissh. nerv. deyatel'nosti im. I.P. Pavlova. 2008. 58, N 6. P. 718-727.
Dunaeva T.Yu., Trofimova L.K., Graf A.V., Maslova M.V., Maklakova A.S., Krushinskaya Ya.V., Sokolova N.A. Transgeneratsionnie effekti antenatal'noi ostroi gipoksii perioda rannego organogeneza . Byul. eksperim. biologii i meditsini. 2008. 146, N 10. P. 364-366.
Zhuravin I.A., Tumanova N.L., Potapov D.O.StrukVliyanie turnie izmeneniya v sensomotornoi kore mozga v rannem postnatal'nom ontogeneze kris, perenesshih prenatal'nuyu gipoksiyu . Zhurn. evolyuts. biohimii i fiziologii. 2001. 37, N 6. P. 518-520.
Kassil' V.G., Otellin V.A., Hozhai L.I., Kostkin V.B. Kriticheskie periodi razvitiya golovnogo mozga . Ros. fiziol. zhurn. 2000. 86, N 11. P. 1129-1136.
Morozov V.I., Chaikovskii V.S., Priyatkin S.A., Ro- gozhkin V.A., Savchenko O.M. Radioimmunologicheskii analiz steroidov, nauchno-prakticheskie aspekti) . Fiziol. zhurn. SSSR. 1988. 74, N 8. P. 473-476.
Pal'chik A.B., Shabalov N.P. Gipoksicheski-ishemiche- skaya entsefalopatiya novorozhdennih. S-Pb.: PITER, 2001. 224 p.
Stroev S.A., Tyul'kova E.I., Vataeva L.A., Samoilov M.O., Pel'to-H'yukko M.T. Vliyanie prenatal'noi gi- poksii na ekspressiyu tioredoksina-1 v gippokampe kris na raznih srokah postnatal'nogo ontogeneza . Neirohimiya. 2011. 28, N 3. P. 226-231.
Tyul'kova E.I., Vataeva L.A., Samoilov M.O. Vliyanie prenatal'noi gipobaricheskoi gipoksii na aktiv- nost' fosfoinozitidnoi sistemi mozga kris . Zhurn. evolyuts. biohimii i fiziologii. 2010. 46, N 5. P. 406-409
Tyul'kova E.I., Vataeva L.A., Samoilov M.O., Otellin V.A. Mehanizmi formirovaniya reaktsii mozga na dei- stvie gipobaricheskoi gipoksii v razlichnie sroki prenatal'nogo perioda u kris . Zhurn. akusherstva i zhenskih boleznei. 2010. 59, N 4. P. 99-110.
Tyul'kova E.I., Semenov D.G., Vataeva L.A., Belyakov A.V., Samoilov M.O. Vliyanie prenatal'noi gipoba- richeskoi gipoksii na aktivnost' glutamatergicheskoi signal'noi transduktsii mozga kris . Byul. eksperim. biologii i meditsini. 2011. 151(3). P. 224-228.
Boksa P. Animal models of obstetric complications in relation to schizophrenia.Brain Res. Rev. 2004. 45. P. 1-17.
Cai Z., Xiao F., Lee B., Paul J. A., Rhodes P. G. Prenatal hypoxia-ischemia alters expression and activity of nitric oxide synthase in the young rat brain and causes learning deficits . Brain Res. Bull. 1999. 49, N 5. P. 359-365.
Choi D.C., Furay A.R., Evanson N.K., Ostrander M.M., Ulrich-Lai Y.M., Herman J.P. Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic- pituitary-adrenal axis activity: implications for the integration of limbic inputs . J. Neurosci. 2007. 27(8). P. 2025-2034.
Cullinan W.E., Zaborszky L. Organization of ascending hypothalamic projections to the rostral forebrain with special reference to the innervation of cholinergic projection neurons . J. Comp. Neurol. 1991. Apr 22. 306(4). P. 631-667.
Florian C., Roullet P. Hippocampal CA3-region is crucial for acquisition and memory consolidation in Morris water maze task in mice . Behavioural. Brain Res. 2004. 154, N 2. P. 365-374.
Golan H., Huleihel M. The effect of prenatal hypoxiaon brain development^ short- and long-term consequences demonstratrd in rodent models . Developmental. Sci. 2006. 9. P. 338-349.
Herman J.P., Patel P.D., Akil H., Watson S.J. Localization and regulation of glucocorticoid and mineralocorticoid receptor messenger RNAs in the hippocampal formation of the rat . Mol Endocrinol. 1989. 3(11). P. 1886-1894.
Jason J.R., Kristin L.G., Paul E.S. A. Discrete GABAergic relay mediates medial prefrontal cortical inhibition of the neuroendocrine stress response . J. Neurosci. 2009. 29(22). P. 7330-7340.
Khozhai L.I., Otellin V.A., Kostkin V.B. Formation of the neocortex in rats after prenatal hypoxia . Neurosci. and Behav. Physiol. 2004. 34, N 2. P. 207-211.
Lipp H.P., Wolfer D.P. Genetically modified mice and cognition . Curr. Opin. Neurobiol. 1998. 8, N 2. P. 272-280.
O’Neill C. Phosphatidylinositol 3-kinase signaling in mammalian preimplantation embryo development . Reproduction. 2008. 136. P. 147-156.
Paxinos G., Watson C. The rat brain in stereotaxic coordinates. Sydney: Acad. Press. 1986.
Schopke R, Wolfer D. P., Lipp H. P., Leisinger-Trigona M. C. Swimming navigation and structural variations of the infrapyramidal mossy fibers in the hippocampus of the mouse . Hippocampus. 1991. 1, N 3. P. 315-328.
Wimer C.C., Wimer R.E., Roderick T.H. Some behavioral differences associated with relative size of hippocampus in the mouse . J. Comp. Physiol. Psychol. 1971. 76. P. 57-65.
Winick M .Cellular growth during early malnutrition .Pediatrics. 1971. 47, N . P. 969-978.
|
