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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(6): 111-115


The effect of mild hypobaric hypoxia regime on expression of factor induced by hypoxia in the rat neocortex

Sidorova MV1, Rybnikova EA1, Churilova AV1, Portnichenko VI2, Sanoĭlov MO1

  1. Pavlov Institute of Physiology, RAS, St.Petersburg, Russia
  2. International Centre for Astronomical, Medical and Ecological Research, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.06.111

Abstract

Using quantitative immunohistochemistry, modifications of HIF-1alpha expression in neocortex of rats exposed to various modes of mild hypobaric hypoxia (MHH) (1,3 and 6 episodes) differed in their neuroprotective efficacy have been studied. It has been shown that three-trial MHH being the most effective neuroprotective mode when used as a preconditioning produces most considerable changes in HIF-1 by substantial up-regulation of its regulatory alpha-subunit expression in the rat neocortex. Present findings support the hypothesis on important roles of HIF-1 in the mechanisms of brain hypoxic tolerance induced by the hypoxic preconditioning with three-trial MHH.

Keywords: mild hypobaric hypoxia, neuroprotective effect,hypoxia-inducible factor HIF-1.

References

  1. Luk'yanova L.D., Kirova Yu.I., Sukoyan G.V. Signal'nie mehanizmi adaptatsii k gipoksii i ih rol' v sistemnoi regulyatsii. Obzor . Biol. membrani. 2012. 29, N 4. P.238-253.
  2.  
  3. Maslov L.N., Lishmanov Yu.B., Emel'yanova T.V., Prut D.A., Kolar F.3, Portnichenko A.G., Podoksenov Yu.K., Haliulin I.G., Vang H., Pei Zh. M. Gipoksicheskoe prekonditsionirovanie, kak novii podhod k profilaktike ishemicheskih i reperfuzionnih povrezhdenii golovnogo mozga i serdtsa . Angiologiya i sosudistaya hirurgiya. 2011. 17, N 3. P.27-36.
  4.  
  5. Portnichenko V.I., Nosar' V.I., Portnichenko A.G., Drevitskaya T.I., Sidorenko A.M., Man'kovskaya I.N. Fazovie izmeneniya energeticheskogo metabolizma pri gipoksii . Fiziol. zhurn. 2012. 58, N 4. P.3-12.
  6.  
  7. Samoilov M.O. Reaktsii neironov mozga na gipoksiyu. L : Nauka. 1985. 190 p.
  8.  
  9. Samoilov M.O., Ribnikova E.A. Molekulyarno-kletochnie i gormonal'nie mehanizmi indutsirovannoi tolerantnosti mozga k ekstremal'nim faktoram sredi (obzor) . Ros. fiziol. zhurn. im.I.M.Sechenova. 2012. 98(1). P.108-126.
  10.  
  11. Samoilov M.O., Ribnikova E.A., Churilova A.V. Signal'nie molekulyarnie i gormonal'nie mehanizmi protektivnih effektov gipoksicheskogo prekonditsionirovaniya . Patol. fiziologiya i eksperim. terapiya. 2012. N 3. P. 3-10.
  12.  
  13. Serebrovskaya T.V. Gipoksiya-indutsibel'nii faktor: rol' v patofiziologii dihaniya. Obzor . Ukr. pul'mon. zhurn. 2005. N 3. P. 77-81.
  14.  
  15. Churilova A.V., Glushchenko T.S., Samoilov M.O. Izmeneniya neironov gippokampa i neokorteksa kris pod vliyaniem razlichnih rezhimov gipobaricheskoi gipoksii . Morfologiya. 2012. 141 (1). P.7-11.
  16.  
  17. Obrenovitch T.P. Molecular physiology of preconditioning-induced brain tolerance to ischemia . Physiol. Rev. 2008. 88. P. 211-247.  CrossRef PubMed
  18.  
  19. Ogunshola O.O., Antoniou X. Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration? . Cell. Mol. Life. Sci. 2009. 66, N 22. P. 3555-563.  CrossRef PubMed
  20.  
  21. Rybnikova E, Sitnik N, Gluschenko T, Tjulkova E and Samoilov M The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats . Brain Res. 2006. 1089, N 1. P.195-202. CrossRef PubMed
  22.  
  23. Rybnikova E., Vataeva L., Tyulkova E., Gluschenko T., Otellin V., Pelto-Huikko M., and Samoilov M. Preconditioning prevents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia . Beh. Brain. Res. 2005. 160, N 1. P.107-114. CrossRef PubMed
  24.  
  25. Sharp F.R., Ran R., Lu A., Tang Y., Strauss K.I., Glass T., Ardizzone T., Bernaudin M. Hypoxic preconditioning protects against ischemic brain injury . NeuroRx. 2004. 1, N 1. P. 26-35. CrossRef PubMed PubMedCentral
  26.  
  27. Siesjo B.K., Bengtsson F. Calcium fluxes, calcium antagonists, and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression:a unifying hypothesis . J. Cereb. Blood Flow Metab. 1989. 9, N 2. P.244-252. CrossRef PubMed
  28.  
  29. Taie S., Ono J., Iwanaga Y., Tomita S., Asaga T., Chujo K., Ueki M. Hypoxia-inducible factor-1 alpha has a key role in hypoxic preconditioning . J. Clin. Neurosci. 2009. 16, N 8. P.1056-1060. CrossRef PubMed
  30.  
  31. Webb J.D., Coleman M.L., Pugh C.W. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing . Cell. Mol. Life Sci. 2009. 66(22). P.3539-3554. CrossRef PubMed
  32.  
  33. Weidemann A., Johnson R.S. Biology of HIF-1alpha . Cell Death Differ. 2008. 15, N 4. P.621-627. CrossRef PubMed
  34.  

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