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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(6): 111-115

The effect of mild hypobaric hypoxia regime on expression of factor induced by hypoxia in the rat neocortex

Sidorova MV1, Rybnikova EA1, Churilova AV1, Portnichenko VI2, Sanoĭlov MO1

  1. Pavlov Institute of Physiology, RAS, St.Petersburg, Russia
  2. International Centre for Astronomical, Medical and Ecological Research, NAS of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.06.111


Abstract

Using quantitative immunohistochemistry, modifications of HIF-1alpha expression in neocortex of rats exposed to various modes of mild hypobaric hypoxia (MHH) (1,3 and 6 episodes) differed in their neuroprotective efficacy have been studied. It has been shown that three-trial MHH being the most effective neuroprotective mode when used as a preconditioning produces most considerable changes in HIF-1 by substantial up-regulation of its regulatory alpha-subunit expression in the rat neocortex. Present findings support the hypothesis on important roles of HIF-1 in the mechanisms of brain hypoxic tolerance induced by the hypoxic preconditioning with three-trial MHH.

Keywords: mild hypobaric hypoxia, neuroprotective effect,hypoxia-inducible factor HIF-1.

Full text: (PDF, in Russian)

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