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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(6): 43-48

Participation of eicosanoids in the mechanisms of contractile reactions of the portal vein to adrenaline and noradrenaline

Ianchuk PI, Vynohradova OO, Pasichnichenko OM, Kostenko SS

    Taras Shevchenko National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.06.043


The influence of indometacine (7 x 10(-8)M) on the tonic contractile activity of the isolated rat portal vein (PV) under the action of adrenaline (1 x 10(-5)M) and noradrenaline (5 x 10(-6)M) was studied. Indometacine decreased the amplitude of noradrenaline-induced tonic constriction of PV with intact endothelium and produced no effect on constriction of vessels with denuded endothelial layer. The results suggest that these reactions are mediated by endothelial prostanoids. Inhibition of adrenaline-induced constriction of PV preparations with intact and denuded endothelium suggests that the contractile reactions are mediated by prostanoides derived from both endothelial and smooth muscle cells.

Keywords: adrenaline, noradrenaline, portal vein, endothelium, prostanoides.

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