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Participation of eicosanoids in the mechanisms of contractile reactions of the portal vein to adrenaline and noradrenaline
Ianchuk PI, Vynohradova OO, Pasichnichenko OM, Kostenko SS
Taras Shevchenko National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.06.043
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Abstract
The influence of indometacine (7 x 10(-8)M) on the tonic contractile activity of the isolated rat portal vein (PV) under the action of adrenaline (1 x 10(-5)M) and noradrenaline (5 x 10(-6)M) was studied. Indometacine decreased the amplitude of noradrenaline-induced tonic constriction of PV with intact endothelium and produced no effect on constriction of vessels with denuded endothelial layer. The results suggest that these reactions are mediated by endothelial prostanoids. Inhibition of adrenaline-induced constriction of PV preparations with intact and denuded endothelium suggests that the contractile reactions are mediated by prostanoides derived from both endothelial and smooth muscle cells.
Keywords:
adrenaline, noradrenaline, portal vein, endothelium, prostanoides.
References
Avakyan O.M. Farmakologicheskaya regulyatsiya funktsiiadrenoretseptorov. M.: Meditsina, 1988. 256 s
- Katusic Z.S., Shepherd J.T., Vanhoutte P.M. Endotheliumdependentcontractions to calcium ionophore A23187,arachidonic acid and acetylcholine in canine basilararteries . Stroke. 1988. N 19. P.476-479.
CrossRef
PubMed
- Usui H., Kurahasi K., Shirahase H. Endotheliumdependentvasocontraction in response to noradrenaline in the caninecerebral artery . Jap. J. Pharmacol. 1987. N 44. P.228-231.
- Roberts R.E., Kendall D.A., Wilson V.G. ?2adrenoceptorand NPY receptormediated contractions of porcineisolated blood vessels: evidence for involvement of thevascular endothelium . Brit. J. Pharmacol. 1999. N 128. P.1705-1712.
CrossRef
PubMed PubMedCentral
- Blattner R., Klassen H., Denert H., Dyoring H. Eksperimenti na izolirovannih preparatah gladkih mishts. M.: Mir, 1983. 206 p.
- Yanchuk P.I., Pasichnichenko O.M., Komarenko V.I., Prihod'ko T.P., Tsibenko V.O. Z'yasuvannya mehanizmivzvuzhuval'noi dii atsetilholinu na vnutrishn'opechinkovi voritni sudini . Fiziol. zhurn. 2006. 52, N 5. P.23-28.
- Marta S., Mercedes C. Human vascular smooth muscle cellsbut not endothelial cells express prostaglandin E . Circ.Res. 2000. N 87. P.504-507.
Stansby G., Shukla N., Hamilton G. Comparison ofprostanoid synthesis in cultured human vascular endothelialcells derived from omentum and umbilical vein . Eur. J.Vascular Surgery. 1991. 5, N 5. P.501-506
CrossRef
- Furuhashi N., Miyazaki S., Kamura M. Role of endotheliumand vasoconstrictor prostanoids in norepinephrineinducedvasoconstriction in isolated rat common carotid arteries. Clin.Exp.Hypertens. 2000. 22, N 5. P.543-554.
CrossRef
PubMed
- Chaudhari A., Pedram A., Kirschenbaum M.A. Prostanoidbiosynthesis in cultured rabbit renal microvascular smoothmuscle cells. Effect of arachidonic acid, calcium, andA23187 . Lab. Invest. 1990. 63, N 1. P.30-37.
PubMed
- Ody C., Duval D. Arachidonate incorporation andprostaglandin production in cultured endothelial andsmooth muscle cells from pig aorta . ProstaglandinsLeukot Med. 1983. 11, N 1. P.63-72.
CrossRef
- Hassid A., Williams C. Vasoconstrictorevoked prostaglandinsynthesis in cultured vascular smooth muscle. Amer. J. Physiol. Cell Physiol. 1983. 245, N 3. P.278-282.
CrossRef
PubMed
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