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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(5): 56-60

Influence of intranasal administration of dopamine on realization of cognitive processes and locomotor activity of rats during stress

Kruchenko ZhO, Pil'kevych NO

    A.A. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv, Ukraine


In spontanepously hypertensive rats (SHR) we studied the influence of intranasal administration of dopamine (DA) on realization of food operant conditioned reflex (OCR) and motor activity (locomotion, bars, stopping beating, grooming) in a interstimulation period in a norm and in the conditions of stressed influences. The state of sharp stress was caused by application of intensive acoustic irritation is a loud sound operating during realization ofOCR. Stress caused a brake of conditioned reflex activity, immobilization ofanimals, weakening of attention to the conditional stimulus. On a background intranasal application DA (0.15 mgs/of kg) the effect of stress on voice irritation was eliminated, not rendering brake influence on OCR and motor activity. DA via oppressing the reactions of alarm and fear strengthened the focused attention that assisted the improvement of integrative function in the concrete situation of realization of OCR.

Keywords: dopamine, intranasal administration operant conditionedreflex (ОCR), motor activity, stress, rots.


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