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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(5): 56-60

Influence of intranasal administration of dopamine on realization of cognitive processes and locomotor activity of rats during stress

Kruchenko ZhO, Pil'kevych NO

    A.A. Bogomoletz Institute of Physiology, National Academyof Science of Ukraine, Kyiv, Ukraine


In spontanepously hypertensive rats (SHR) we studied the influence of intranasal administration of dopamine (DA) on realization of food operant conditioned reflex (OCR) and motor activity (locomotion, bars, stopping beating, grooming) in a interstimulation period in a norm and in the conditions of stressed influences. The state of sharp stress was caused by application of intensive acoustic irritation is a loud sound operating during realization ofOCR. Stress caused a brake of conditioned reflex activity, immobilization ofanimals, weakening of attention to the conditional stimulus. On a background intranasal application DA (0.15 mgs/of kg) the effect of stress on voice irritation was eliminated, not rendering brake influence on OCR and motor activity. DA via oppressing the reactions of alarm and fear strengthened the focused attention that assisted the improvement of integrative function in the concrete situation of realization of OCR.

Keywords: dopamine, intranasal administration operant conditionedreflex (ОCR), motor activity, stress, rots.


  1. Vein A.M., Golubev V.L., Berzin'sh Yu.E. Riga: Zinatne, 1981. 362 p.
  3. Golubev V.L., Levin Ya.I., Vein A.M. Bolezn' Parkinsonai sindrom Parkinsonizma. M.: Medpress, 1999. 416 p.
  5. Krizhanovskii G.N., Karaban' I.N., Magaeva S.V., Kucheryanu V.G., Karaban' N.V. Bolezn' Parkinsona. M.:Meditsina, 2002. 335 p.
  7. Rodina V.I., Krupina N.A., Krizhanovskii G.N., OkninaN.F. Mnogoparametrovii metod kompleksnoi otsenkitrevozhnofobicheskih sostoyanii u kris . Zhurn. vissh.nerv. deyatel'nosti. 1993. 43, N 5. P. 10061017.
  9. Shoven R. Povedenie zhivotnih. M.: Mir, 1972. 489 p.
  11. Advokat C. Update on amphetamine neurotoxicity and its relevance to the treatment of ADHD. J. Atten. Disord. 2007. 11. P. 816. CrossRef PubMed
  13. Arnsten A.F. Stimulants: therapeutic actions in ADHD. Neuropsychopharmacol. 2006. 31. P. 23762383. CrossRef PubMed
  15. Buddenberg T.E., Topic B., Mahiberg E.D., de Souza Silva M.A., Huston J.P., Mattern C. Bihavioral actions of intranasal application of dopamine: effects on forced swimming, elevated plusmaze and open field parameters . Neuropsychobiol. 2008. 57. P. 7079. CrossRef PubMed
  17. Chemuturi N.V., Haraldsson J.E., Prisinzano T., Donovan M. Role of dopamine transporter (DAT) in dopamine transport across the nasal mucosa . Life Sci. 2006. 79. P. 13911398.Dahlin M., Jansson B., Bjork E. Levels of dopamine in bloodand brain following nasal administration to rats . Eur. J.Pharm. Sci. 2001. 14. P. 7580.
  19. Graff C.L., Pollack G.M. Nasal drug administration; potential for targeted central nervous system delivery. Pharm. Sci. 2005. 94. P. 11871195. CrossRef PubMed
  21. Heijtz R.D., Kolb B., Forssberg H. Motor inhibitory roly of dopamine D1 receptors: implications for ADHD . Physiol. Behav. 2007. 92. P. 155160. CrossRef PubMed
  23. Horst R.O., Hendren R.L. Integrated pharmacologic treatment of attentiondeficit hyperactivity disorder (ADHD) .Essend. Psychopharmacol. 2005. 6. P. 250261.
  25. Huber S.J., Cummings J. Parkinson"s disease. Neurobehavioral Aspects. New York: Oxford University Press, 1992. 368 p.
  27. Illum L. Transport of drugs from the nasal cavity to the central nervous system . Eur. J. Pharm. Sci. 2000. 11. P. 118. CrossRef  
  28. Kazushige M., Mitsutoshi Yuzurihara, Atsushi Ishige, Hiroshi Saaki, DeHua Chui, and Takeshi Tabira. Chronic Stress induces impairment of spatial working memory becous of prefrontal Dopaminergic Dysfunction . Y.Neurcience. 2000. 20, N 4. P. 15681574.
  30. Lucia A.Ruocco, Maria A. de Souza Silva, Blanca Topic. Intranasal application of dopamine reduces activity and improves attention in Naples High Excitability rats that feature the mesocortical variant of ADHD . Europ. Neuropsichopharmacol. 2009 19. P. 693701.
  32. MehlerWex C., Riederer P., Gerlach M. Dopaminergic dysbalance in distinct basal ganglia neurocircuits: implications for the pathophysiology of Parkinson's disease, schizophrenia and attention deficit hyperactivity disorder . Neurotox. Res. 2006. 10 P. 167179.
  34. Schwab R.S., Lieper Y. Effect of mood, motivation, stress, and alertness of the performance jn Parkinson"s disease . Psychiat. Neurol. (Basel). 1965. 150 P. 345357.
  36. Sikstrom S., Soderlund G. Stimulusdependent dopamine release in attentiondeficit. hyperactivity disorder . Psychol.Rev. 2007. 114. P. 10471075. CrossRef PubMed
  38. SonugaBarke E.J. The dual pathway model of AD. HD: an elaboration of neurodevelopmental characteristics . Neurosci. Biobehav. Rev. 2003. 27 P. 593604.
  40. de Souza Silva M.A., Topic B., Huston J.P., Mattern C. Intranasal dopamine application increases dopaminergic activity inthe neostriatum and nucleus accumbens and enhances motor activity in the open field . Synapse. 2008. 62. P.176184. CrossRef PubMed
  42. Thorne R.G., Frey W.H. Delivery of neurotrophic factors to the central nervous system: pharmacokinetic considerations . Clin. Pharmacokinet. 2001. 40. P. 907946. CrossRef PubMed

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