Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(5): 20-24


Peculiarities of sexual behavior of female rats with hyperandrogenia in pubertal and postpubertal periods

Nosenko ND, Lymarieva AA

    State Institution “V.P. Kommissarenko Institute of Endocrinology and Metabolism, National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.05.020

Abstract

The parameters of female and male sexual behavior in 3- and 6- month old female rats which were exposed to an androgen excess (subcutaneous implantation of Silastic capsules containing 5 mg of crystalline testosterone) from the beginning of pubertal period (at the age of 35 days), or within postpubertal period (at the age of 4 months). Hyperandrogenia in pubertal period had no effect on female sexual behavior formation, but it led to appearance of male behavior components in 100% of animals. In female rats which were implanted with testosterone capsules in postpubertal period, sexual disturbances were more pronounced and were characterized by masculinization and defeminization, which was due to a higher degree of androgenic saturation. The data obtained suggest a leading role of hyperandrogenemia in the pathogenesis of sexual behavior disturbances in female rats in different periods of individual development.

Keywords: sexual behavior, hyperandrogenia, pubertal andpostpubertal period, female rats.

References

  1. Nosenko N.D., Ganzhii I.Yu, Sinitsin P.V., Polyakova L.I.,Tarasenko L.V., Limarieva A.A., Chaikovs'ka L.V., Sachins'ka O.V., Reznikov O.G. Vpliv hronichnogo stresu pid chas pubertatsii na reproduktivnu sistemusamits' shchuriv z eksperimental'noyu giperandrogeniieyu . Fiziol. zhurn. 2011. 57, N 2. P. 27-34.
  2.  
  3. Reznikov O.G. Mehanizmi rozvitku funktsional'noi patologii reproduktsii ta adaptatsii v rann'omu ontogenezi . Zhurn. AMN Ukraini. 1998. N 2. P. 216-233.
  4.  
  5. Reznikov A.G., Nosenko N.D., Boris E.N., Polyakova L.I., Sinitsin P.V., Tarasenko L.V. Izuchenie effektivnosti gonadotropnih induktorov ovulyatsii u kris s giperandrogeniei v usloviyah primeneniya flutamida . Probl. endokrinologii. 2011. 57,N 4. P. 28-31.
  6.  
  7. Reznikov O.G., Sinitsin P.V., Tarasenko L.V., Polyakova L.I. Neiroendokrinni mehanizmi rozvitku anovulyatornogo sindromu giperandrogennogo pohodzhennya u shchuriv . Fiziol. zhurn. 1995. 41, N 5-6. P. 33-37.
  8.  
  9. Chernuha G.E. Sovremennie predstavleniya o sindrome polikistoznih yaichnikov . Ginekol. endokrinologiya. 2002. 4, N 8. P. 24-27.
  10.  
  11. Uitlou Dzh. Kogda osobenno ne vovremya sindrom polikistoza yaichnikov u podrostkov . Novaya meditsina tisyacheletiya. 2008. N 6. P. 7-9.
  12.  
  13. Dorner G., Docke F., Moustafa S. Differential localization of a male and a female hypothalamic mating center . J. Reprod. Fert. 1986. 17. P. 582-586.
  14.  
  15. Foecking E.M., McDevitt M.A., Acosta-Martinez M., Horton T.H., Levine J.E. Neuroendocrine cosequences of androgen excess in female rodents . Horm.Behav. 2008. 53, N 5. P. 673-692. CrossRef PubMed PubMedCentral
  16.  
  17. Hoepfner B.A., Ward I.L. Prenatal and neonatal androgen exposure interact to affect sexual differentiation in female rats . Behav. Neurosci. 1988. 102. P. 61-65. CrossRef PubMed
  18.  
  19. Rodriguez-Medina M., Sanchola E., Vergara-Onofre M., Rosado A. Ca2+/calmodulin system: Participation on sexual hypothalamic differentiation . Pharmacol. Biochem. Behav. 1993. 46. P. 697-702. CrossRef  
  20. Schwarz J.M., McCarthy M.M. Cellular mechanisms of estradiol-mediated masculinization of the brain . J. Steroid Biochem.Molec.Biol 2008. 109, N 3-5. P. 300-306. CrossRef PubMed PubMedCentral
  21.   Schwarz J.M., McCarthy M.M. The role of neonatal NMDA receptor activation in defeminization and masculinization of sex behavior in the rat . Horm. Behav.2008. 54, N 5. P. 662-668 CrossRef PubMed PubMedCentral

© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2019.