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Fiziologichnyi Zhurnal - <a id="lj1_ret_bk_to_jl0_href_id" href="?list0=15">Fiziol. Zh. 2013;</a> <a id="lj1_ret_bk_to_jl0_href_id" href="?list1=77">59(4):</a> 28-32
Українська Русский English

ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(4): 28-32


The effect of Ca2+ on the properties of the large conductance cation channels of the nuclear envelope of the cerebellar neurons

Lun'ko OV, Fedorenko OA, Marchenko SM

    O.O. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.04.028

Abstract

Previously we have found the large conductance cation channels (LCCC) in the nuclear membranes, where inositol-1,4,5-triphosphate receptors (IP3Rs) were also observed. Probably IP3Rs and LCCC are functionally connected: LCCC may provide the counterflow of K+, which prevent the formation of the negative potential in the lumen of the nuclear envelope and in such way may prolong the Ca2+ releasing by IP3Rs. LCCC are poorly studied and their molecular nature is still unknown. We investigated the effect of Ca2+ on properties of these channels. Our results demonstrated the main biophysical properties of LCCC changed significantly neither in Ca(2+)-free solution, nor with high concentrations of Ca2+ in the nuclear lumen. So, the level of Ca2+ repletion of the store does not influence the activity of LCCC.

Keywords: nuclear envelope, ion channels, calcium store

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