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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(3): 31-38


Effects of diphenyl derivatives on electrophoretic mobility of murine T lymphocytes

Dolga OV1, Pogoriela NKh1, Bohorad-Kobel's'ka OS2, Zholobak NM2, Zanoza SO3, Liakhov SA3, Mahura IS1

  1. О.О. Bogomoletz Institute of Physiology National Academy of Sciences of Ukraine, Kyiv, Ukraine
  2. D.K. Zabolotny Institute of microbiology and virology National Academy of Sciences of Ukraine, Kyiv, Ukraine
  3. O.V. Bogatsky Physicо-Chemiсal Institute National Academy of Sciences of Ukraine, Odesa, Ukraine
DOI: https://doi.org/10.15407/fz59.03.031

Abstract

The early changes of electrophoretic mobility (EPM) of murine T lymphocytes induced by structural analogues of amixine-dihydrochloryde 4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 1) and dihydrochloryde 2-methoxycarbonil-4,4'-bis-[2(diethylamino)ethoxy]diphenyl (compound 2) were studied by electrophoresis technique. During the interval 0-2 hours all compounds increased the absolute values of EPM in comparison with control. These changes were of the same kind--distinctions were quantitative. Amixine and compound 1 during the interval 2-4 hours additionally increased the EPM. The compound 2, on the contrary, decreased the EPM. It was shown that the opposite effects of the aforementioned compounds were caused by the fact that amixine and compound 1 induce, and compound 2 does not induce IFN production in T lymphocytes in vitro. The results of our experiments are important for understanding of the mechanisms of immunomodulating effect of amixine and its structural analogues.

Keywords: amixine, diphenyl derivatives, interferon inducers,T lymphocytes, electrophoretic mobility

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