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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(2): 111-121

Role of neural stem cells in regeneration of the central nervous system

Rybachuk OA, Pivneva TA.

    O.O. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.02.111


Abstract

Central nervous system (CNS) of adult mammalian and, in particular of people, is a typical example of organs that are not restored. However, the growing interest in the development of innovative treatments that are aimed at the regeneration damaged tissue CNS is based on the latest research in the field of stem cells and neurology. The recapitulation of normal neural development has become a vital strategy for CNS regeneration. Normal CNS development is initiated by the induction of stem cells in the CNS, i.e., neural stem cells (NSCs). Thus, the introduction or mobilization of NSCs could be expected to lead to CNS regeneration by recapitulating normal CNS development, in terms of the activation of the endogenous regenerative capacity and cell transplantation therapy. In this review we summarized the recent progress in study of basic stem cell biology, on the prospective identification of NSCs, the elucidation of the mechanisms of ontogenic changes, potential differentiation, and their therapeutic applications.

Keywords: embryonic stem cells, neural stem cells, neurogenesis,neurosphere, induced pluripotent stem cells.

Full text: (PDF, in Ukrainian)

References

  1. Zaporozhan VN, Bazhora Yu.I. Stem Cells. K .: Odessa: Odessa.gos.med.un.-t. 2004 228 p.
    2.  
  2. Zozulya Yu.A., Lisyaniy NI, Tsymbalyuk VI, Semenova VM Neurogenic differentiation of stem cells. K .: UIPK "ExBr". 2005. 368 p. Tsymbalyuk V.I., Medvedev V.V. Neurogenic stem cells. K .: "Koval". 2005. 596 c.
    3.  
  3. Tsymbalyuk V.I., Medvedev V.V. Neurogenic stem cells.  K .: "Koval".  2005.  596 c.
  4. Altman J, Das GD. Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats . J. Comp. Neurol. 1965. 124, N 3. P. 319-335. CrossRef PubMed
    5.  
  5. Alvarez-Buylla A., Garcia-Verdugo J.M., Tramontin A.D. An unified hypothesis on the lineage of neural stem cells . Nat. Rev. Neurosci. 2001. 2. P. 287-293. CrossRef PubMed
    6.  
  6. Amariglio N., Hirshberg A., Scheithauer B.W., Cohen Y., Loewenthal R., Trakhtenbrot L., Paz N., Koren-Michowitz M., Waldman D., Leider-Trejo L., Toren A., Constantini S., Rechavi G. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient . PLoS Med. 2009. 6, N 2. Suppl.
    7.  
  7. Amemiya K., Haruta M., Eguchi G. Adult human retinal pigment epithelial cells capable of differentiating into neurons . Biochem. and Biophys. Res. Cammun. 2004. 316, N 1. P. 1-5. CrossRef PubMed
    8.  
  8. Arsenijevic Y., Villemure J. G., Brunet J. F., Bloch J. J., Deglon N., Isolation of multipotent neural precursors residing in the cortex of the adult brain . Exp.Neurol. 2001. 170, N1. P. 48-62. CrossRef PubMed
    9.  
  9. Bailey K. J., Maslov A. Y., Pruitt S. C. Accumulation of mutations and somatic selection in aging neural stem/ progenitor cells . Aging Cell. 2004. 3, N 6. P. 391-397. CrossRef PubMed
    10.  
  10. Bakogiannis C., Tousoulis D., Androulakis E., Briasoulis A., Papageorgiou N., Vogiatzi G., Kampoli A.M., Charakida M., Siasos G., Latsios G., Antoniades C., Stefanadis C. Circulating endothelial progenitor cells as biomarkers for prediction of cardiovascular outcomes . Curr Med. Chem. 2012. 19, N 16. P. 2597-2604. CrossRef PubMed
    11.  
  11. Bandyopadhyay A., Dong Q., Sun L.Z. Stem/progenitor cells in murine mammary gland: isolation and functional characterization . Methods Mol. Biol. 2012. 879. P. 179-193. CrossRef PubMed
    12.  
  12. Cameron H.A., McKay R.D. Restoring production of hippocampal neurons in old age . Nat. Neurosci. 1999. 2, N10. P. 894-897. CrossRef PubMed
    13.  
  13. Corotto F.S., Henegar J.A., Maruniak J.A. Neurogenesis persist in the subependumal layer of the adult mouse brain . Neurosci. Lett. 1993. 149, N 2. P. 111-114. CrossRef  
  14. Cummings B.J., Uchida N., Tamaki S.J., Salazar D.L., Hooshmand M., Summers R., Gage F.H., Anderson A.J. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice . Proc. Natl. Acad. Sci. USA. 2005. 102, N 39. P. 14069-14074. CrossRef PubMed PubMedCentral
    15.  
  15. Day R.M. Epithelial stem cells and tissue engineered intestine . Curr. Stem. Cell Res Ther. 2006. 1, N 1. P. 113-120 CrossRef PubMed
    16.  
  16. Eriksson P.S., Perfilieva E., Bjork-Eriksson T., Alborn A.M., Nordborg C., Peterson D.A., Gage F.H. Neurogenesis in the adult human hippocampus . Nat. Med. 1998. 4, N 11. P. 1313-1317. CrossRef PubMed
    17.  
  17. Fujita S. The matrix cell and cytogenesis in the developing central nervous system . J. Comp.Neurol. 1963. 120. P. 37-42. CrossRef PubMed
    18.  
  18. Gage F. N. Mammalian neural stem cell . Science. 2000. 287, N 5457. P. 1433-1438. CrossRef PubMed
    19.  
  19. Good P, Yoda A, Sakakibara S, Yamamoto A, Imai T, Sawa H, Ikeuchi T, Tsuji S, Satoh H, Okano H. The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells . Genomics. 1998. 52, N 3. P. 382-384 CrossRef PubMed
    20.  
  20. Gritti A., Bonfanti L., Doetsch F., Caille I., Vescovi A.L. Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents . J. Neurosci. 2002. 22, N 2. P. 437-445. CrossRef PubMed
    21.  
  21. Harkness L., Prokhorova T.A., Kassem M., Blagoev B. Stable isotope labelling with amino acids in cell culture for human embryonic stem cell proteomic analysis . Methods Mol Biol. 2012. 873. P.297-305. CrossRef PubMed
    22.  
  22. Higushi Y., Nakamura H., Takahashi S. The dynamics of precursor cells in the olfactory epithelium of juvenile and adult guinea pigs . Eur. Arch. Otorhinolaryngol. 2004. 43. P. 148-153.
    23.  
  23. Horiguchi S., Takahashi J., Kishi Y., Hashimoto N. Neural precursor cells derived from human embryonic brainretain regional specificity . J. Neurosci. Res. 2004. 75, N 6. P. 817-824. CrossRef PubMed
    24.  
  24. Horner P., Power A., Palmer T., Gage F. Proliferation and differentiation of progenitor cells throughout the infact adult rat spinal cord . J. Neurosci. 2000. 20, N 6. P. 2218-2228. O.A.Ribachuk, T.a. Pivneva 120 ISSN 0201-8489 Fiziol. zhurn., 2013, T. 59, N 2
    25.  
  25. Jang Y., Park J., Lee M., Yoon B., Kim S. Retinoic acidmediated induction of neurons and glial cells from human umbilical cord hematopoietic stem cells . J. Neurosci. Res. 2004. 75, N 4. P. 573-584. CrossRef PubMed
    26.  
  26. Jenny B., Kanemitsu M., Tsupykov O., Potter G., Salmon P., Zgraggen E., Gascon E., Skibo G., Dayer A.G., Kiss J.Z. Fibroblast growth factor-2 overexpression in transplanted neural progenitors promotes perivascular cluster formation with a neurogenic potential. Stem Cells. 2009. 27, N 6. P. 1309-1317. CrossRef PubMed
    27.  
  27. Johansson C.B., Momma S., Clake D.L. Identification of neural stem cell in the adult mammalian central nervous system . Cell. 1999. 96, N 1. P. 25-34. CrossRef  
  28. Kaneko Y., Sakakibara S., Imai T., Suzuki A., Nakamura Y., Sawamoto K., Ogawa Y., Toyama Y., Miyata T., Okano H. Musashi-1: an evolutionally conserved marker for CNS progenitor cells including neural stem cells . Dev. Neurosci. 2000. 22, N 1-2. P. 138-152. CrossRef PubMed
    29.  
  29. Kempermann G., Gage F.H. New nerve cells for the adult brain . Sci. Amer. 1999. 280. P. 48-53. CrossRef PubMed
    30.  
  30. Koch P., Kokaia Z., Lindvall O., Bruestle O. Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling . Lancet Neurol. 2009. 8, N9. P. 819-829. CrossRef  
  31. Kriegstein A., Noctor S., Mart?ґnez-Cerdeno V. Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion . Nat. Rev. Neurosci. 2006. 7. P. 883-890. CrossRef PubMed
    32.  
  32. Limke T.L., Rao M.S. Neural stem cell therapy in the aging brain: pitfalls and possibilities . J. Hematother. Stem. Cell. 2003. 12, N 6. P. 615-623. CrossRef PubMed
    33.  
  33. Luskin M.B. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone . Neuron. 1993. 11. P. 173-189. CrossRef  
  34. Maslov A.Y., Barone T.A., Pruitt S. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice . J. Neurosci. 2004. 24, N 7. P. 1726-1733. CrossRef PubMed
    35.  
  35. McKay R. Stem cells in the central nervous system . Science. 1999. 276, N 5309. P. 66-71. CrossRef  
  36. Morshead C.M., Kooy D. v. d. Disguising adult neural stem cells . Curr. Opin. Neurobiol. 2004. 14, N 1. P. 125-131. CrossRef PubMed
    37.  
  37. Okano H., Imai T., Okabe M. (2002) Musashi: atranslational regulator of cell fates .J. Cell Sci. 2002. 115, N (Pt 7). P. 1355-1359.
    38.  
  38. Okano H., Kawahara H., Toriya, M., Nakao K., Shibata S., Takao, I. Function of RNA binding protein Musashi-1 in stem cells . Exp. Cell Res. 2005. 306. P. 349-356. CrossRef PubMed
    39.  
  39. Okano H. Neural stem cells and strategies for the regenerationof the central nervous system . Proc. Jpn. Acad., Ser. B 86. 2010. 86. P. 438-450.
    40.  
  40. Okano H. Neural stem cells: progression of basic research and perspective for clinical application . Keio J. Med. 2002. 51. P. 115-128. CrossRef PubMed
    41.  
  41. Okano H., Sawamoto K. Neural stem cells: involvement in adult neurogenesis and CNS repair . Phil. Trans. R. Soc. 2008. 363. P. 2111-2122. CrossRef PubMed PubMedCentral
    42.  
  42. Okano H. Stem cell biology of the central nervous system . J. Neurosci. Res. 2002. 69, N 6. P. 698-707. CrossRef PubMed
    43.  
  43. Okano H., Temple S. Cell types to order: Temporal specification of CNS stem cells . Curr. Opin. Neurobiol. 2009. 19. P. 112-119. CrossRef PubMed
    44.  
  44. Pagano S., Impagnatiello F., Girelli M., Cova L., Grioni E., Onofri M. Isolation and characterization of neural stem cells from the adult human olfactory bulb . Stem Cell. 2000. 18, N 4. P. 295-300. CrossRef PubMed
    45.  
  45. Palmer T.D., Ray J., Gage F.H. FGF-2-responsive neuronal progenitors reside in proliferative and quiscent regions of the adult rodent brain . Mol. Cell. Neurosci. 1995. 6, N 5. P. 474-486. CrossRef PubMed
    46.  
  46. Pincus D., Keyoung H., Restelli C., Sakakibara S., Okano H., Goodman R. FGF2/BDNF-associated maturation of new neurons generated from adult human subependymal cells . Ann. Neurol. 1998. 43. P.576-585. CrossRef PubMed
    47.  
  47. Rakic P. Evolution of the neocortex: a perspective from developmental biology . Nat. Rev.Neurosci. 2009. 10. P. 724-735. CrossRef PubMed PubMedCentral
    48.  
  48. Ramon y Cajal, S. Degeneration and regeneration of the nervous system. (Translated by RM Day from the 1913 Spanish edition). Oxford, University Press, Oxford. 1928.
    49.  
  49. Reynolds B.A., Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system . Science. 1992. 255, N 5052. P. 1707-1710. CrossRef PubMed
    50.  
  50. Richards L.J., Kilpatric T.J., Bartlett P.F. De novo generation of neuronal cells from the adult mouse brain . PNAS USA. 1992. 89, N 18 P. 8591-8595. CrossRef PubMed PubMedCentral
    51.  
  51. Sakakibara S., Imai T., Hamaguchi K., Okabe M., Aruga J., Nakajima K., Yasutomi D., Nagata T., Kurihara Y., Uesugi S., Miyata T., Ogawa M., Mikoshiba K., Okano H. Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell . Dev Biol. 1996. 176, N 2. P. 230-242. CrossRef PubMed
    52.  
  52. Sakakibara S., Okano H. Expression of neural RNAbinding proteins in the post-natal CNS: implication of their roles in neural and glial cells development . J. Neurosci. 1997. 17, N 21. P. 8300-8312. CrossRef PubMed
    53.  
  53. Sato K., Hayashi T., Abe K. Temporal and spatial differences of PSA-NCAM expression of neural markers in human umbilicat cord blood . Exp. Neurol. 2001. 922, N 1. P. 135-139.
    54.  
  54. Shihabuddin L., Horner P., Ray J., Gage F. Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gurys . J. Neurosci. 2000. 20, N 23. P. 8727-8735. CrossRef PubMed
    55.  
  55. Smith R., Bagga V., Fricker-Gates R. Embryonic neural progenitor cells: the effects of species, region, and culture conditions on longterm proliferation and neuronal differentiation . J. Hematother. Stem Cell Res. 2003. 12, N6. P. 713-725. CrossRef PubMed
    56.  
  56. Suzuki S.O., Goldman J.E. Multiple cell populations in the early postnatal subventricular zone dake distinct migratory pathways: adynamic study of glial and neuronal progenitor migration . J. Neurosci. 2003. 23, N 10. P. 4240-4250. PubMed
    57.  
  57. Temple S., Alvarez-Buylla A. Stem cells in the adult mammalian central nervous system . Curr. Opin. Neurobiol. 1999. 9. P. 135-141. CrossRef  
  58. Temple S. The development of neural stem cells . Nature. 2001. 414, N 6859. P. 112-117. CrossRef PubMed
    59.  
  59. Tropepe V., Hitoshi S., Ekker M. Neural stem cells and their progeny express region-specific gene in the developing CNS, but this expression is not irreversible and can be altered by lokal inductive cues . Soc. Neurosci. Abstr. 2000. 23, N 1. P. 107-121.
    60.  
  60. Tsupykov O. M., Pivneva T. A, Poddubna A. O., Kyryk V. M., Kuchuk O. V, Butenko G. M., Skibo G.G. Migration and differentiation of fetal neural progenitor cells in the brain of ischemic animals . IJPP. 2010. 1, N 1. P. 25-34. CrossRef  
  61. van Praag H., Schinder A., Gage F. Functional neurogenesis in the adult hippocampus . Nature. 2002. 415, N 6875. P. 1030-1034. CrossRef PubMed
    62.  
  62. Wright N.A. Stem cell identification--in vivo lineage analysis versus in vitro isolation and clonal expansion. . J. Pathol. 2012. 227, N 3. P. 255-266. CrossRef PubMed
    63.  
  63. Yagita Y., Kitagawa K., Matsumoto M. Neurogenesis by progenitor cells in the ischemic adult rat hippocampus . Stroke. 2001. 32, N 8. P. 1890-1896. CrossRef PubMed
    64.  
  64. Yao J., Mu Y., Gage F.H. Neural stem cells: mechanisms and modeling . Protein Cell. 2012. 3, N7. P. 559. CrossRef PubMedCentral
    65.  
  65. Yoshida N., Hishuyama S., Hisatsune T. Decrease in expression of ?5?1-integrin during neuronal differentiation of cortical progenitor cells . Exp. Cell. Res. 2003. 287, N 1. P. 240-254. CrossRef  

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