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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(2): 85-91


Pathogenetic substantiation of using peptidases in the treatment of patients with generalized periodontitis

Serheieva IIe

    National Medical University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.02.085

Abstract

76 patients of whom 52 patients with GP-II degree exacerbative and 24 somatically healthy people aged 20-50 years were studied. Based on these immunological examination serapeptydase was assigned per os, as a complementary product to the basic therapy. Any concentration of secretory leukocyte protease inhibitor (SLPI) indicates the dominant hyperergic inflammation in periodontal tissues, accompanied by increased proteolysis. Profitable accumulation in the serum of patients with GP inhibitors proteinase to 53%, IL-1beta - to 26.3%, IL-2 - to 19.5%, IL-8 - to 42.8% FNPalpha - up to 48.3%, and reduction of IFNalpha to 78.1% indicates changes of complex "protease-antiproteases" immunocompetent cells and activation of inflammatory processes at the local and systemic levels.

Keywords: generalized periodontitis, cytokines, SLPI (secretoryleukocyte protease inhibitor), TNF-б, IFN-б, phagocyticindex, phagocytic number.

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