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ISSN 2522-9028 (Print)
ISSN 2522-9036 (Online)
DOI: https://doi.org/10.15407/fz

Fiziologichnyi Zhurnal

is a scientific journal issued by the

Bogomoletz Institute of Physiology
National Academy of Sciences of Ukraine

Editor-in-chief: V.F. Sagach

The journal was founded in 1955 as
1955 – 1977 "Fiziolohichnyi zhurnal" (ISSN 0015 – 3311)
1978 – 1993 "Fiziologicheskii zhurnal" (ISSN 0201 – 8489)
1994 – 2016 "Fiziolohichnyi zhurnal" (ISSN 0201 – 8489)
2017 – "Fiziolohichnyi zhurnal" (ISSN 2522-9028)

Fiziol. Zh. 2013; 59(2): 31-38


Effect of L-arginine on the oxygen balance of the liver and its bile secretion function

Ianchuk PI, Bondzyk OV, Reshetnik IeM, Vesel's'kyĭ SP

    Taras Shevchenko Kyiv National University, Kyiv, Ukraine
DOI: https://doi.org/10.15407/fz59.02.031

Abstract

In acute experiments on anesthetized rats we showed that L-arginine causes an increase in oxygen-dependent synthetic processes in the liver, particularly associated with mitochondrial polyenzyme systems biosynthesis of bile acids with simultaneous activation in hepatocytes tissue respiration. The level of oxygen tension in the gland is not changed. Implementation of these effects partly involves nitric oxide. In addition, the L-arginine inhibits cholepoiesis without involving to the reaction NO. Dose-dependent influence L-arginine on the bile cholates content may indicate a different effect of this amino acids on metabolic transformation of bile acids such as hydroxylation and conjugation.

Keywords: liver, L-arginine, L-NAME, oxygen balance,cholepoiesis, bile acids

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