|
|
|
|
|
|
Effect of chronic sensorineural hearing loss at several indicatorsof immune and endocrine systems of children 7–11 years
S.P. Beschasnyi
Kherson state university, Kherson, Ukraine
DOI: https://doi.org/10.15407/fz59.01.110
![](/images/cite.png)
Abstract
We investigated the effects of chronic bilateral sensorineural
hearing loss of III–IV degree on the performance of interleukins,
immunoglobulins serum and saliva, the functional activity
of granulocyte-monocyte cell immunity, evaluated the activity
of the hypothalamic-pituitary-adrenal system in children
aged 7–11 years. It was found that due to stress activation of the
sympathetic-adrenal system the function of granulocytes and
monocytes is suppressed, with a predominance of production
of anti-inflammatory interleukins. This leads to the dominance
of T-helper type 2. Products granulocytes and T-helper type-2
anti-inflammatory interleukins IL-4, IL-5, IL-10, IL-13 leads
to the activation of B-cells. Thus, in children 7-11 years of
age with congenital bilateral sensorineural hearing loss is a
decrease of non-specific humoral immunity dominated type
of immune response to increased levels of IgG.
Keywords: sensorineural hearing loss, interleukins, granulocytes,
phagocytosis.
Keywords:
sensorineural hearing loss, interleukins, granulocytes,phagocytosis.
References
- Grebenyuk I.E. Etiopatogeneticheskie aspekti senso nevral'noi tugouhosti: avtoref. dis. ... kand. med. nauk. M., 2007. 22 s.
- Zolotova T. V. Differentsial'nii podhod k lecheniyu sensonevral'noi tugouhosti: avtoref. dis. ... d-ra med. nauk. M., 2004. 41 s.
- Laboratornie metodi issledovaniya v klinike: Spra- vochnik / pod red. V.V. Menshikova. M.: Meditsina, 1987. 368 s.
- Mel'nikov O.F.,. Sidorenko T.F., Zayats T.a., Timen G.E., CHaschevaya E.G. autoimmunnie reaktsii gumoral'nogo i kletochnogo tipov na antigeni nervnoi tkani u detei s sensonevral'noi tugouhost'yu . ZHurn. vushnih, nosovih i gorlovih hvorob. 2003. N6. S. 5-8.
- Nugumanov a.a. autoimmunnie zabolevaniya vnutren- nego uha i metodi ih lecheniya: avtoref. dis. … kand. med. nauk. Sankt-Peterburg, 2008. 28 s.
- Timen G.E. Mel'nikov O.F., Pisanko V.N., Sambur M.B., Golod a.N. Kliniko-audiologicheskie priznaki auto- immunnoi SNT . ZHurn. vushnih, nosovih i gorlovih hvorob. 2000. N 6. S. 105-108.
- CHascheva O.G. Kliniko-imunologichni aspekti v diagnostitsi ta likuvanni ditei z se nsonevral'noyu prigluhuvatis- tyu: avtoref. dis. ... kand. med. nauk. K., 2007. 20 s.
- Bednarska K., Klink M., Sulowska Z. Application of in- tracellular alkaline phosphatase activity measurement in detection of neutrophil adherence in vitro . Mediators In?amm. 2006. 4. P. 19307-19312.
- Broughton S.S., Meyerhoff W.E., Cohen S.B. Immune- mediated inner ear disease: 10-year experience . Semin. Arthritis. Rheum. 2004. 34, N2. P.544-548.
CrossRef
PubMed
- Garcia Berrocal J.R., Berrocal, R. Ramirez-Camacho Sudden sensorineural hearing loss: supporting the im- munologic theory . Ann. Otol. Rhinol. Laryngol. 2002. N 111. P. 989-997.
CrossRef
PubMed
- Pellme S., Dahlgre N.C., Karlsson A. The two neutrophil plasma membrane markers alkaline phosphatase and HLA class I antigen localize differently in granule-de?cient cytoplasts. An ideal plasma membrane marker in human neutrophils is still lacking . J. Immunol. Methods. 2007. 325. P. 1562-1570.
CrossRef
PubMed
- Reddy M.V., Satyanarayana V.V., Hemabindu L. Immu- nological studies in children with hearing impairment . Indian. Med. Assoc. 2005. 103, N 10. P.520-521.
|
|
|
|
|
|
|
© National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2014-2024.
|
|